Skip to main content

What are vaccines and how do they work?

What are vaccines and how do they work?

Speak To An Expert

Get clear, personalised advice for your situation.

Jot down a few questions to make the most of your conversation.


What are Vaccines?

Vaccines are biological preparations designed to provide immunity against specific infectious diseases. They are composed of weakened or inactivated parts of a particular organism (antigen) that triggers an immune response within the body. By stimulating this response, vaccines prepare the immune system to recognize and combat the disease-causing pathogen if encountered in the future. Vaccines have been pivotal in controlling and even eradicating diseases, such as smallpox and polio, that once posed significant threats to public health.

How Do Vaccines Work?

Vaccines work by training the immune system to recognize and fight pathogens, such as viruses or bacteria. When a vaccine is introduced into the body, it mimics the disease-causing microorganism without causing the illness. This exposure prompts the immune system to respond by producing antibodies, which are proteins developed by the body to neutralize or destroy toxins and disease agents. Importantly, the immune system also produces memory cells that persist long-term, enabling faster and stronger immune responses upon subsequent exposures to the pathogen.

There are several types of vaccines, each utilizing different mechanisms to provoke an immune response:

  • Inactivated Vaccines: These contain inactivated or killed pathogens. They cannot cause disease but still prompt a protective immune response. The influenza vaccine is an example of an inactivated vaccine.
  • Live Attenuated Vaccines: These vaccines use a weakened form of the germ that causes a disease. Because they are so similar to the natural infection they help prevent, they create a strong and long-lasting immune response. Examples include the measles, mumps, and rubella (MMR) vaccine.
  • Subunit, Recombinant, Polysaccharide, and Conjugate Vaccines: These vaccines use pieces of the germ like its protein, sugar, or capsid. They target the essential antigens needed for a robust immune response. The hepatitis B vaccine is a subunit vaccine.
  • Toxoid Vaccines: These are made using toxins that have been inactivated (toxoids) so they can no longer cause harm. Toxoid vaccines are used to protect against diseases where toxins generated by bacteria cause illness, such as tetanus.
  • Messenger RNA (mRNA) Vaccines: These newer vaccines, among the latest technological advancements, utilize messenger RNA to instruct cells to make a protein similar to one found in the virus, triggering an immune response without using live virus particles. The COVID-19 vaccines developed by Pfizer-BioNTech and Moderna are examples.

The Importance of Vaccines

Vaccination is crucial for personal and public health. It not only helps protect vaccinated individuals but also provides herd immunity, reducing the likelihood of disease outbreaks. This is particularly important for individuals who cannot be vaccinated, such as those with certain medical conditions or weakened immune systems. By maintaining high vaccination rates, we can prevent the resurgence of diseases that have been brought under control or eliminated.

What are Vaccines?

Vaccines are medicines that help protect us from getting sick from certain diseases. They contain tiny parts of germs that can't make us ill. This helps our body learn how to fight the germs if we meet them in the future. Vaccines have helped stop diseases like smallpox and polio from spreading and making people very sick.

How Do Vaccines Work?

Vaccines teach our body how to fight germs like viruses and bacteria. When we get a vaccine, it acts like the germ but doesn’t make us sick. This helps our body make something called antibodies to fight the germs. Our body also remembers how to fight the germ if we see it again later.

There are different types of vaccines:

  • Inactivated Vaccines: These use germs that are dead. They help protect us without causing illness. The flu shot is an example.
  • Live Attenuated Vaccines: These use a weak form of the germ. They help our body build a strong defense. The MMR vaccine, for measles, mumps, and rubella, is one example.
  • Subunit, Recombinant, Polysaccharide, and Conjugate Vaccines: These use just parts of the germ. They help the body make a strong defense. An example is the hepatitis B vaccine.
  • Toxoid Vaccines: These use germs' toxins that can't harm us. They help prevent diseases like tetanus.
  • Messenger RNA (mRNA) Vaccines: These are newer vaccines. They teach cells to make a harmless piece of a protein from the germ to build defense. COVID-19 vaccines from Pfizer-BioNTech and Moderna are examples.

The Importance of Vaccines

Getting vaccinated is important. It keeps us healthy and protects others too. This stops diseases from spreading. Some people, like those who are very sick, cannot get vaccines. By getting vaccines, we help keep everyone safe. Continuing to get vaccines can stop diseases from coming back.

Frequently Asked Questions

A vaccine is a biological preparation that provides active acquired immunity to a particular infectious disease.

Vaccines work by stimulating the immune system to recognize and fight pathogens, such as viruses or bacteria, without causing the disease.

Vaccines are important because they protect individuals and communities from infectious diseases, helping to prevent epidemics and save lives.

The main types of vaccines are inactivated, live-attenuated, subunit, and mRNA vaccines. Each type uses different methods to trigger an immune response.

Herd immunity occurs when a large portion of a community becomes immune to a disease, reducing its spread and protecting individuals who are not immune.

No, vaccines do not cause the diseases they protect against. They may cause mild symptoms as the body builds immunity, but not the actual disease.

Yes, vaccines are safe. They undergo rigorous testing in clinical trials and are continually monitored for safety once they are in use.

Vaccines are tested for safety in multiple phases of clinical trials, involving thousands of volunteers, before receiving approval from regulatory bodies.

An mRNA vaccine uses messenger RNA to instruct cells in the body to produce a protein similar to one found in the virus, triggering an immune response.

The duration of protection varies by vaccine and individual. Some vaccines provide lifelong protection, while others may require boosters.

Most people can receive vaccines, but some may not be suitable due to allergies or specific health conditions. A healthcare provider can offer guidance.

Common side effects include soreness at the injection site, mild fever, and fatigue. These are typically short-lived and indicate the body is building immunity.

Some vaccines require multiple doses to build and sustain a strong immune response or to boost immunity that decreases over time.

Vaccine development involves extensive research, including laboratory studies and clinical trials, to ensure they are safe and effective before approval.

A live-attenuated vaccine uses a weakened form of the germ that causes a disease, prompting a strong immune response without causing serious illness.

If you experience side effects, it is usually safe to manage them at home with rest and hydration. Consult a healthcare provider if you have severe or persistent symptoms.

No, the flu vaccine cannot give you the flu. Some people may experience mild, flu-like symptoms as the body builds immunity.

A subunit vaccine contains pieces of the pathogen, such as proteins, to stimulate an immune response without including the whole germ.

Vaccines greatly reduce the risk of illness, but no vaccine is 100% effective. Factors like timing, vaccine type, and individual variation can influence protection.

Completing the full vaccine schedule, staying informed about boosters, and maintaining overall health can improve vaccine effectiveness.

A vaccine is a special medicine. It helps your body stay safe from getting sick with certain diseases.

Vaccines help your body learn how to fight germs, like viruses and bacteria, so you don't get sick.

Vaccines are important. They help keep us safe from getting sick. Vaccines protect you and everyone around you. They stop big outbreaks of disease and save lives.

The main kinds of vaccines are inactivated, live-attenuated, subunit, and mRNA vaccines. Each kind uses a different way to help your body fight germs.

Herd immunity is when a lot of people in a community can't get sick from a disease. This makes it harder for the disease to spread and helps keep safe those who can't fight it off.

No, vaccines do not make you sick with the diseases they stop. Sometimes, you might feel a little unwell, but this is just your body getting stronger. You won't get the real disease from a vaccine.

Yes, vaccines are safe. Scientists test them a lot in special trials to make sure they work well. Even after people start using them, experts keep checking that they are safe.

Before vaccines are used by everyone, they are checked to make sure they are safe. This checking happens in different steps and uses many volunteers. After these checks, special groups give the okay for the vaccines to be used.

If you need help reading, you can ask someone to read with you or use an app that reads words out loud.

An mRNA vaccine tells your body how to make a small part of the virus. This helps your body learn to fight the virus if you ever catch it.

How long a vaccine works can be different for each one. Some vaccines keep you safe for your whole life. Other vaccines need extra doses to keep working.

Most people can get vaccines. But some people might not be able to get them because of allergies or health problems. A doctor or nurse can help you know what is best.

After getting the shot, your arm might feel sore. You might also feel a little bit hot, like you have a mild fever. You could feel tired, too. These things usually go away quickly and mean that your body is getting stronger to protect you.

Some vaccines need more than one shot to work well. This helps your body fight off sickness better and for longer. Sometimes, the extra shots help keep you safe because your body's defense can get weaker over time.

Making vaccines takes a lot of work. Scientists do many studies in the lab and test vaccines on people to make sure they are safe and work well. They check everything carefully before saying the vaccine is okay to use.

If you find it hard to read, you can ask an adult to read with you, use audiobooks, or try special reading apps. These can help you understand better.

A live-attenuated vaccine is a type of shot you get to stop people from getting sick. It uses germs that are not strong, so you won't get seriously ill. But your body learns to fight the germs.

If you feel unwell, you can usually feel better at home. Rest and drink lots of water. If you feel really bad or don't get better, talk to a doctor or nurse.

No, the flu shot cannot make you sick with the flu. Some people might feel a little sick after the shot, but this is normal. It means your body is getting ready to fight off the flu.

A subunit vaccine is a type of medicine that helps your body fight germs. It uses only small parts of the germ, like proteins, to teach your body how to stay safe. It does this without giving you the whole germ.

Vaccines help keep us from getting sick. But, they don't work all the time. How well they work can depend on when you get them, the type of vaccine, and how different people are from each other.

Getting all your vaccine shots, learning about extra booster shots, and staying healthy can help vaccines work better.

Important Information On Using This Service


This website offers general information and is not a substitute for professional advice. Always seek guidance from qualified professionals. If you have any medical concerns or need urgent help, contact a healthcare professional or emergency services immediately.

Some of this content was generated with AI assistance. We've done our best to keep it accurate, helpful, and human-friendly.

  • Ergsy carefully checks the information in the videos we provide here.
  • Videos shown by Youtube after a video has completed, have NOT been reviewed by ERGSY.
  • To view, click the arrow in centre of video.
Using Subtitles and Closed Captions
  • Most of the videos you find here will have subtitles and/or closed captions available.
  • You may need to turn these on, and choose your preferred language.
Turn Captions On or Off
  • Go to the video you'd like to watch.
  • If closed captions (CC) are available, settings will be visible on the bottom right of the video player.
  • To turn on Captions, click settings.
  • To turn off Captions, click settings again.