What is the global impact of rabies?

Rabies is a viral disease that affects the central nervous system, causing inflammation in the brain. It is fatal once symptoms appear.

Rabies is primarily transmitted through the bite of an infected animal, most commonly dogs. The virus is present in the saliva of infected animals.

Rabies is responsible for an estimated 59,000 human deaths annually worldwide, with the majority occurring in Asia and Africa.

Rabies has the highest impacts in Asia and Africa, where dog-mediated rabies remains endemic.

Rabies persists due to inadequate control of stray dog populations, insufficient vaccination coverage, and lack of access to healthcare in affected regions.

Dogs are the most common carriers of rabies in many parts of the world, but the disease also affects bats, raccoons, skunks, and foxes.

Rabies can be effectively prevented through the vaccination of domestic animals, public awareness campaigns, and prompt post-exposure prophylaxis for individuals bitten by potentially rabid animals.

PEP is an immediate treatment administered after potential exposure to rabies, consisting of cleaning the wound, administering rabies immunoglobulin, and a series of rabies vaccinations.

Rabies vaccines are highly effective when administered promptly and appropriately. They are crucial in both pre-exposure prophylaxis for high-risk individuals and post-exposure prophylaxis.

Initial symptoms include fever, headache, and general weakness. As the disease progresses, symptoms can include anxiety, confusion, paralysis, hydrophobia, and hallucinations, leading to coma and death.

While challenging, rabies eradication is possible with comprehensive measures such as mass dog vaccination, education, and improved access to vaccines and healthcare.

Bats are significant reservoirs for the rabies virus in many regions, especially in the Americas, and can transmit the virus to humans and other animals.

Rabies poses a threat to wildlife conservation by causing mortality in endangered species and complicating the management of wildlife populations.

Dog vaccination is crucial because it is the most cost-effective strategy to prevent the majority of human rabies cases, as dogs are the primary source of human rabies transmission.

Rabies exerts pressure on public health systems through the demand for PEP, management of rabid patients, and control and prevention activities.

Rabies has significant economic costs, including medical expenses, loss of productivity due to death or time off work, and costs related to animal control and vaccination programs.

Organizations like the World Health Organization (WHO), OIE, and FAO collaborate globally to develop strategies, share information, and provide resources to control rabies.

Challenges include underreporting, lack of laboratory confirmation, inadequate healthcare infrastructure, and insufficient integration of animal health data.

Rabies is considered a neglected tropical disease due to its high incidence in poorer regions, lack of attention and resources, and substantial impact on underserved populations.

Launched by WHO, OIE, and FAO, the Zero by 30 campaign aims to achieve zero human rabies deaths from dog-mediated rabies by 2030 through comprehensive vaccination and education programs.